Visualizing the immune system.
Multimodality preclinical and clinical approaches to image immune response using novel innovative probes
Complex immune responses result in the production and distribution of a variety of immunological precursors and cells throughout multiple organ systems. In order to further illuminate the local and systemic cellular function and migration patterns, our group has developed special non-invasive immuno-imaging methods. Being part of the Biomedical Engineering and Imaging Institute, we are fortunate to have access to a fleet of dedicated preclinical and clinical imaging systems, including PET/MR, PET/CT, high field MR and optical imaging, which can be utilized to study disease status in murine, swine, rabbit and non-human primate models. Using novel radiotracers, we have established approaches to non-invasively monitor immunological processes. Among different applications, we have studied the induction of trained immunity, the egress and migration of myeloid cells in ischemic heart disease and cancer, amygdala metabolic activity as a predictor for cardiovascular events, and local macrophage proliferation and monocyte production as a biomarker for the progression of atherosclerosis. Our lab revels at the opportunity to visualize the immunomodulatory effects of our carefully designed nanoimmunotherapeutics using a range of highly advanced scanners in BMEII’s advanced facilities.
Mount Sinai Hospital opens one of the first centers to study and treat people with what being called “Post-acute COVID Syndrome.”
Please click on the image to watch the 60 Minutes segment. New York, NY (November 22, 2020) — COVID-19 was initially thought to be a disease that was serious for the eldery and people with preexisting conditions. A potentially tough, but temporary respiratory illness...
Nanobiologic immunotherapy uses tiny, bioengineered material to harness immune systemNew York, NY (October 29, 2020) — A groundbreaking new type of cancer immunotherapy developed at the Icahn School of Medicine at Mount Sinai trains the innate immune system to help it...
Led by Robert Hirten, MD and Zahi Fayad, PhD, the study draws upon the collaborative efforts of the Mount Sinai COVID Informatics Center (MSCIC) and is open to all employees in the health system. It uses a unique phone App to administer questions and collect data from...
Artificial intelligence–enabled rapid diagnosis of patients with COVID-19
Xueyan Mei, Hao-Chih Lee, […] Yang Yang
Nat Med (2020).
Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging
Max L. Senders, Anu E. Meerwaldt, ... Willem J. M. Mulder
Nat. Nanotechnol. 15, 398–405 (2020).