Visualizing the immune system.
Multimodality preclinical and clinical approaches to image immune response using novel innovative probes
Complex immune responses result in the production and distribution of a variety of immunological precursors and cells throughout multiple organ systems. In order to further illuminate the local and systemic cellular function and migration patterns, our group has developed special non-invasive immuno-imaging methods. Being part of the Biomedical Engineering and Imaging Institute, we are fortunate to have access to a fleet of dedicated preclinical and clinical imaging systems, including PET/MR, PET/CT, high field MR and optical imaging, which can be utilized to study disease status in murine, swine, rabbit and non-human primate models. Using novel radiotracers, we have established approaches to non-invasively monitor immunological processes. Among different applications, we have studied the induction of trained immunity, the egress and migration of myeloid cells in ischemic heart disease and cancer, amygdala metabolic activity as a predictor for cardiovascular events, and local macrophage proliferation and monocyte production as a biomarker for the progression of atherosclerosis. Our lab revels at the opportunity to visualize the immunomodulatory effects of our carefully designed nanoimmunotherapeutics using a range of highly advanced scanners in BMEII’s advanced facilities.
Led by Robert Hirten, MD and Zahi Fayad, PhD, the study draws upon the collaborative efforts of the Mount Sinai COVID Informatics Center (MSCIC) and is open to all employees in the health system. It uses a unique phone App to administer questions and collect data from...
Technology may lead to rapid diagnosis based on CT scans and patient data Mount Sinai researchers are the first in the country to use artificial intelligence (AI) combined with imaging, and clinical data to analyze patients with coronavirus disease (COVID-19). They...
Center aims to create state-of-the-art medical technology to transform patient care The Mount Sinai Health System announced the creation of the Biomedical Engineering and Imaging Institute (BMEII), the first of its kind in New York City, and one of a few in the world....
Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study
Tawakol A, Ishai A, Takx RA, Figueroa AL, Ali A, Kaiser Y, Truong QA, Solomon CJ, Calcagno C, Mani V, Tang CY, Mulder WJ, Murrough JW, Hoffmann U, Nahrendorf M, Shin LM, Fayad ZA, Pitman RK 2017 Jan 12 · Lancet
Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging
Hectors SJ, Wagner M, Bane O, Besa C, Lewis S, Remark R, Chen N, Fiel MI, Zhu H, Gnjatic S, Merad M, Hoshida Y, Taouli B 2017 May 26 · Sci Rep